Sayzie attended Rhode Island School of Design, and Edinburgh College of Art, majoring in painting. Upon graduation, Manhattan lured her in pursuit of her artistic career. In New York she also studied at the Art Students League. She has had many group and solo shows. She received fellowships from The MacDowell Colony, The Edna St. Vincent Millay Foundation and was granted a studio at PS 122.
Her life always revolved around her studio. To support herself and her painting career she worked in all aspects of the textile field, from designing fabric to working with the renowned international fabric designers for interiors. Her own workshop grew and branched out into many aspects of the textile industry. She produced elaborate sculptural displays for museums and events. She was featured in a special edition of People Magazine for “Design of the 90’s”, numerous articles in the New York Times. In Manhattan Sayzie’s business continued to expand into more and larger projects, such as backdrops, special events, interiors, costumes, and restaurants. In 2005, she decided to devote herself entirely to painting. Presently Sayzie, her husband, and their dog divide their time between Lakeville and New York City.